About Us | Terms of Use and Disclaimer | Privacy Policy | Contact Us | Forum | Advertise With Us. The disorder of the immune system synthesizes antiphospholipid antibodies, an abnormal blood proteins, which is responsible for  aggregation of the blood platelets. Signs of a DVT include pain, swelling and redness. Deep vein thrombosis (DVT) 6. The cause of this abnormality is unknown, but some experimental studies. If you've had episodes of blood clots or pregnancy loss that aren't explained by known health conditions, your doctor can schedule blood tests to check for abnormal clotting and for the presence of antibodies to phospholipids.To confirm a diagnosis of antiphospholipid syndrome, the antibodies must appear in your blood at least twice, in tests conducted 12 or more weeks apart.You can have antiphospholipid antibodies and never develop any signs or symptoms. Following are some other possible symptoms: Neurological problems. Though a relatively new disease, Hughes Syndrome research has made many advances in the past decade. Women have given birth to children even without treatment, though this is not recommended, as Hughes syndrome can increase your risk for premature birth and preeclampsia. Therefore, periodic monitoring of the drug effect specifically bleeding time analysis is important. Stroke (5) Symptoms of Antiphospholipid Syndrome or Hughes Syndrome Stroke- Symptoms of stroke are loss of consciousness, headaches, dementia and seizures. Symptoms of Hughes Syndrome during pregnancy, which include preeclampsia and high blood pressure. Antiphospholipid (AN-te-fos-fo-LIP-id) antibody syndrome (APS) is an autoimmune disorder. (4,5). (1,2,5). Fitz-Hugh-Curtis syndrome is marked by sudden, severe pain in the upper right area of your belly, just below the ribs. Tests which are used for diagnosing of Hughes syndrome looking for molecules of phospholipids in the patients blood. However, studies show that a suspected bacterial or viral infection may trigger the condition. Stroke 1. These clots can travel to your lungs (pulmonary embolism). Other Hughes syndrome symptoms include: Diagnosis of Hughes Syndrome Hughes syndrome can be diagnosed fairly easily. In this complication, multiple clots are generated in different crucial organs, like heart, brain, lungs or liver. Your email address will not be published. Chronic headache due to Migraine 2. Symptomatic discussion also provides some clue of the onset of Hughes syndrome. Other signs and symptoms of APS include chronic (ongoing) headaches, memory loss, and heart valve problems. The phospholipids and proteins that attach to phospholipids are targeted by antiphospholipid antibodies. Hughes’ syndrome can affect the heart and any artery (Hughes, 2001; 2000). Complications Antiphospholipid syndrome (APS), sometimes known as Hughes syndrome, is a disorder of the immune system that causes an increased risk of blood clots. Anticoagulant therapy like heparin, warfarin is prescribed as single or combination therapy for thinning the blood. APS occurs when your body's immune system makes antibodies that attack phospholipids. If you think that you may be suffering from the syndrome, speak with your health care provider and seek appropriate treatment. Questioning about pregnancy related complications like miscarriages are also asked. This means people with APS are at greater risk of developing conditions such as: deep vein thrombosis (DVT), a blood clot that usually develops in the leg Heart valves deformity leads to cardiac disorders 8. Antiphospholipid antibodies increase the activity of your immune system, causing your blood to clot too much. Antiphospholipid syndrome (APS)(2015); NHS choice; Retrieve from: http://www.nhs.uk/conditions/hughes-syndrome/pages/introduction.aspx, Hughes syndrome (2012); Better Health Channel; Retrieve from: https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/hughes-syndrome, Hughes Syndrome Symptoms; London Lupus Center; http://www.londonlupuscentre.co.uk/hughes-syndrome/symptoms/, William C. Shiel Jr.(2015); Antiphospholipid syndrome;  Retrieve from: http://www.medicinenet.com/antiphospholipid_syndrome/article.htm, The antiphospholipid syndrome (Hughes’ syndrome) (2005); retrieve from: http://www.netdoctor.co.uk/conditions/heart-and-blood/a1174/the-antiphospholipid-syndrome-hughes-syndrome/. A stroke happens when an individual has a blood clot in the brain. (1,2,4). 2 Steroidal drugs are given to control the swelling, specifically in case of association with lupus. This could cause blood clots in the placenta, which may prevent your baby from getting the nourishment she needs to grow and develop. Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurring blood clots (thromboses). Young Hughes syndrome: Introduction. They usually help defend the body against infections. APS is a rare immunological disorder characterized by recurring blood clots. More detailed information about the symptoms, causes, and treatments of Young Hughes syndrome is available below.. If you have already suffered from a blood clot, you will likely receive warfarin therapy to help thin your blood. Symptoms of antiphospholipid syndrome depend on where the blood clots form (in arteries or in veins). 1. Complications include: A particularly worrisome complication of the syndrome is called Catastrophic Antiphospholipid Syndrome. Types of Hughes Syndrome There are two types of Hughes Syndrome: Symptoms of Hughes Syndrome The symptoms of Hughes syndrome are sometimes hard to discern, and many patients don't realize that they have it until they suffer from a blood clot. Phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. Autoimmune disorders occur if the body's immune system makes antibodies that attack and damage tissues or cells. Find out what treatments are available. The etiology of his complication is due to stocky nature of blood do not frequently pass through placental barrier and insufficient blood and nutrients supply from mother to the fetus cause repetitive miscarriage and other complication like stillbirth or preterm delivery. Aspirin is usually the recommended treatment during pregnancy. Red rashes develops in the skin, which have a net like outline (livedo reticularis) 3. It is not safe for long-term use because it causes bone loss, which puts you at a risk for osteoporosis. This can be life-threatening. HSF offers understanding and support to sufferers of Hughes Syndrome which is known medically as antiphospholipid syndrome (APS). Other symptoms of the disorder that might come about as result of a blood clot are a stroke or a miscarriage. Heparin is occasionally used in pregnancy when aspirin is ineffective or can't be tolerated. This is a fetal rarely occurs complication related to Hughes syndrome. Hughes disease is sometimes called Antiphospholipid Syndrome, after the type of antibodies that cause the stickiness of the blood. Involuntary jerking movements of the arms or legs 1. (1). This sticky blood can be very dangerous, and puts patients at risk for circulation problems, blood clots, and recurrent miscarriage. Often seen in lupus patients, people suffering from Hughes syndrome have thicker-than-normal blood, due to the fact that their blood platelets tend to stick to one another. The symptoms of Hughes syndrome are sometimes hard to discern, and many patients don't realize that they have it until they suffer from a blood clot. Treatment for Hughes Syndrome Hughes syndrome can be treated successfully using straightforward medications. Hughes Syndrome and Pregnancy If you are suffering from Hughes syndrome, you should receive treatment before trying to conceive. Slurred speech 2. 2. Have you suffered from a number of miscarriages but don't know why? Deep vein thrombosis (DVT) Arterial thrombosis. Alternatively, Hughes syndrome is also known as Antiphospholipid syndrome (APS). Learn about antiphospholipid syndrome symptoms and prognosis, as well as how it relates to pregnancy complications like miscarriage and premature birth. It mostly affects the legs, but clots may also form in the kidneys, lungs, and other organs. It works well in preventing blood clots, but it is only available through injections. Antiphospholipid syndrome (APS) is an autoimmune disorder with no cure, but plenty of people with APS never have symptoms. Secondary Hughes syndrome: This type is associated with the other health related problem which may affect the distant part of the body, including autoimmune diseases like systemic lupus erythematosus. Lesions can appear on the heart valves and the associated arteries. Symptoms that are characteristic only for Antiphospholipid syndrome include:thrombosis, migraine headaches, heart attack loss of memory, red rash in the form of seals, cramps, bruises, dry eyes, etc. APS can cause: 1. Diagnosis - Antiphospholipid Antibody Syndrome Blood cells. The most frequently observed sign and symptoms in Hughes syndrome arise due to lack of treatment. Other complications of pregnancy include dangerously high blood pressure (preeclampsia) and premature delivery. Thrombus formation in the arteries 7. Thrombocytopenia (reduced blood platelet count) 4. A stroke can occur in a young person who has antiphospholipid syndrome but no known risk factors for cardiovascular diseases. Common symptoms of APS include cardiovascular disease, epilepsy, headache, cognitive dysfunction and dementia, movement disorders, multiple sclerosis, and neuropsychiatric disorders. Heart attack. Circulatory symptoms. Blood clots in your legs (DVT). The Hughes Syndrome Foundation's (HSF) mission is to provide information and education on Hughes Syndrome and support research for it. Bleeding At 14 Weeks Any Experiences Advice Please, primary Hughes syndrome, in which the illness appears without lupus, secondary Hughes syndrome, in which the illness manifests as a symptom of lupus, purple-blue discoloration of the skin, particularly around the knees and elbows, blood clots that prevent blood from getting to vital organ. Depending upon the above mentioned results, doctors may order a blood test which can detect the presence of responsible antibiodies i.e. As this clotting can affect any blood vessel anywhere in the body, it can cause a range of possible symptoms, some of which - pins and needles, balance difficulties, fatigue, and visual disturbances - … It is a disease that affects the blood and makes it more likely to clot than normal - a thrombophilia. Women who receive treatment during pregnancy often have pregnancy success rates of over 85%. Antihypertensive drugs are prescribed for hypertensive patient and diabetes control measure should be taken to control diabetes, as hypertension or diabetes can increase the risk of stroke, heart attack or other related complications. People with APS may also experience any of the following symptoms: A blood test will then be performed looking for the presence of antiphospholipid antibodies. (5), Hughes syndrome can arise at any age, even infants and young aged children also get affected with this disease. Aspirin Daily doses of aspirin are usually enough to keep most patients' blood from clotting. target the body’s own phospholipids, and also proteins that bind to phospholipids, which misbalances the cellular structure and leads to different cellular problems. Antiphospholipid syndrome (APS) is an autoimmune disorder.Signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. In the Hughes syndrome, arteries as well as veins can get affected. Antiphospholipid syndrome (APS), also known as Hughes syndrome, is a disorder of the immune system that causes an increased risk of blood clots and miscarriages. Therefore, the probability of certain disorders are increased, like deep vein thrombosis, cardiac problems or stroke, in severe cases central nervous system disorders such as dementia, ataxia, vision impairment, speech difficulty and multiple sclerosis are also included. As the main symptoms of Hughes syndrome is the increased tendency of blood clots, the treatment is aimed at thinning the blood to reduce the risk. Medicines like aspirin is prescribed in low doses for impeding the platelet aggregation. Young Hughes syndrome: A sex linked condition that is characterised by mental retardation and hypogonadism. Other Hughes syndrome symptoms include: unexplained and recurrent miscarriages A syndrome is a collection of events or symptoms that constitutes a specific illness. Mottled skin tone (livedo reticularis) Low blood platelet count (thrombocytopenia) Vein thrombosis. Phospholipids provide the outline of the phospholipid membranes that enclose the cellular organelles and helps to maintain the proper cellular content. Treatment to thin the blood may be with drugs, such as aspirin. Some people with a condition called immune thrombocytopenic purpura (ITP) have antiphospholipid antibodies. Sun City West Arizona Rheumatologist Doctors physician directory - Also called Hughes syndrome, the results of antiphospholipid syndrome can be catastrophic for a pregnant woman. However, the list of related symptoms can be endless, and we all have a different story.