It mostly affects the legs, but … Hughes who worked at the Louise Coote Lupus Unit at St Thomas' Hospital in London. The signs and symptoms of antiphospholipid antibody syndrome (APS) are related to abnormal blood clotting. A lace-like, purple mottled rash called livedo reticularis can occur - usually on the legs. Tests which are used for diagnosing of Hughes syndrome looking … Skin problems. … It is sometimes called 'sticky blood', and is also known as antiphospholipid syndrome (APS). It is being increasingly recognised throughout the world, and in some countries in the Far East and in the Caribbean, it has overtaken rheumatoid arthritis in prevalence. Hughes syndrome, or antiphospholipid antibody syndrome (APS), is an autoimmune condition that causes thickening of the circulating blood. Antiphospholipid syndrome (APS) – also known as Hughes syndrome, lupus anticoagulant and phospholipid antibody syndrome – is an autoimmune disorder that is characterized by excessive clotting of blood in the arteries and veins. Symptoms of Hughes syndrome are varied but the most common is blood clots, particularly in the legs which is known as deep vein thrombosis. It is a disease that affects the blood and makes it more likely to clot than normal - a thrombophilia. This is termed "catastrophic Hughes syndrome". Abstract. Phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. Antiphospholipid syndrome is an acquired autoimmune disorder characterised by recurrent arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of anticardiolipin antibodies and/or evidence of circulating lupus anticoagulant (these abnormalities are detected by blood tests). According to the Epilepsy Foundation, clinical trials showed that the risk is only 0.3 percent for … Look for pain or tenderness, swelling or … The immune system produces abnormal blood proteins called antiphospholipid antibodies, which cause blood platelets to clump together. The risk of getting a serious rash from Lamictal is low. Lupus is a major disease of the immune system, in which a wide variety of antibodies are produced. In the 1980 s, Dr. Hughes and his colleagues provided additional understanding of this disorder. Hughes syndrome is named after the rheumatologist Dr. Graham R.V. Hughes syndrome is known by other names. Clots can reduce or block blood flow. Blood clots can form in, or travel to, the arteries or veins in the brain, heart, kidneys, lungs, and limbs. APS occurs when your body's immune system makes antibodies that attack phospholipids. The outcome of a blood clot depends on its size and location. The condition is named after Dr Graham Hughes, who discovered it in 1983. Hughes syndrome is a condition where clots (thromboses) form in the blood vessels. Symptoms that are characteristic only for Antiphospholipid syndrome include:thrombosis, migraine headaches, heart attack loss of memory, red rash in the form of seals, cramps, bruises, dry eyes, etc. Antiphospholipid syndrome is an immune disorder in which abnormal antibodies are linked to abnormal blood clots in veins and arteries. Antiphospholipid syndrome (APS) is an autoimmune disorder.Signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. APS is sometimes called Hughes' syndrome. Hughes syndrome rash or livedo reticularis: a red rash with a netlike pattern; Less common symptoms include: chronic headaches, migraines, dementia, and seizures: may occur if a blood clot blocks blood flow to certain parts of your brain; cardiovascular disease: blood clots may damage your heart valves